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Is a celiac vaccine in the future?

An Australian research team reports the new findings in the July 21 Science Translational Medicine. The breakthrough work isolating three partial peptides has opened the way for development of a therapeutic vaccine that might help celiac patients tolerate foods that contain celiac. The research team, led by study coauthor Robert Anderson, a gastroenterologist at the Royal Melbourne Hospital and the Walter and Eliza Hall Institute of Medical Research in Parkville, Australia is reporting their findings. http://www.sciencenews.org/view/generic/id/61321/title/Separating_wheat_from_chaff_in_celiac_disease

Celiac patients usually deal with their condition by avoiding wheat, rye and barley. Most people digest these cereals effortlessly, but people with celiac disease have a genetic predisposition that causes an aberrant immune response to gluten. This response damages the walls of the small intestine and sabotages their ability to absorb food. Celiac disease can cause painful bloating, diarrhea, constipation, lethargy and other problems.

The Australian team has begun an early-stage clinical trial using these peptides in a vaccine that aims to desensitize celiac patients and make them tolerant of the compounds. The group expects to report preliminary safety results later this year.

Would you take this vaccine to help your celiac disease?


2 Responses

  1. I would not take this. For celiacs, it’s like developing a vaccine against arsenic. Arsenic is poison; you shouldn’t eat it. Gluten is poison for celiacs; they shouldn’t eat it either.

    Another concern I have about this is that many celiacs have never been tested for other food allergies, like with the ELISA test. They might be vaccinated against gluten, but still be highly allergic to dairy, soy, or egg.

    It would be nice if there were an antidote for celiacs that they could take if they accidentally ingest gluten. But I’m not interested in a vaccine and all the junk it’s likely to contain.

    Thanks for posting this!


  2. I think a vaccine for Celiac disease would be great, but I worry about all vaccines in general. Are they tested long enough, are they contaminated with other potentially dangerous materials?

    Once you get a handle on avoiding celiac in foods, life becomes a lot easier. It just becomes a way of life.


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